Predictors of Favorable ITI Response

• Consistently recognized predictors of ITI success
  

  –	Peak historical inhibitor titre ≤200 BU mL-1
  –	Inhibitor titre <10 BU mL-1 before ITI initiation
  –	Peak inhibitor titre during ITI ≤200 BU mL-1

• Other predictors of better outcomes
  

  –	Age <8 years at start of ITI
  –	ITI initiated <5 years after inhibitor diagnosis
  –	Interruptions in ITI <2 weeks in duration

 

Mark T. Reding, MD Associate Professor of Medicine Director, Center for Bleeding and Clotting Disorders University of Minnesota Medical Center	Valentino L. et al. Haemophilia. 2015;21:559-567.